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Dermal macrophages are located in close proximity to hair follicles, in the surrounding connective tissue sheath and help regulate the hair growth cycle (Eichmuller et al.
(2014) found that apoptosis of skin- resident macrophages activated epithelial hair follicle stem cells, which contribute to hair regeneration (Castellana et al.
Macrophage-specific Wnt-signaling was shown to be central to this process; when it was inhibited, hair follicle growth was delayed.
Apoptosis of macrophages occurred immediately prior to hair follicles' transition from telogen to anagen-the hair cycle's resting and growth phases, respectively.
Although there is more research linking macrophages to hair follicles rather than sweat or sebaceous glands, there is still evidence that macrophages can also respond to cues in the microenvironment created by these appendages.
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